LIN28B Antibody

Lin-28 homolog B (LIN28B) acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. LIN28B acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. LIN28B specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. It also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q6ZN17].
    Product Specifications
    Catalog # Size Price
    LIN28B AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 1 and 50
    A303-588A100 µl (0.2 mg/ml) $339Add to Cart
    A303-588A-M100 µl (10 blots) $229Add to Cart
    A303-588A-T20 µl (2 blots) $50Add to Cart
    LIN28B AntibodyReactivity: Human
    Applications: IP, IHC-P, IF
    Immunogen: Between 200 and 250
    A303-589A100 µl (1 mg/ml) $339Add to Cart
    A303-589A-T10 µl (1 mg/ml) $50Add to Cart

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