LIN28B Antibody

Lin-28 homolog B (LIN28B) acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. LIN28B acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. LIN28B specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. It also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q6ZN17].
    Product/Catalog #SpecificationsPrice
    LIN28B Antibody
    A303-588A
    Reactivity: Human
    Applications: WB, IP
    $314.00
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    LIN28B Antibody
    A303-589A
    Reactivity: Human
    Applications: IP, IHC-P, IF
    $314.00
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    LIN28B Antibody AbVantage™ Pack
    A311-319A
    Applications: WB, IP, IHC-P, IF
    Reactivity: Human
    Quantity: 1 each of A303-588A and A303-589A
    $437.00
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