LARG Antibody

LARG (leukemia-associated RhoGEF) is homologous to PDZ-RhoGEF and functions as a RhoA-specific guanine nucleotide exchange factor. RhoGEFs catalyze the exchange of GDP for GTP on the GTPase, Rho, to activate downstream signaling pathways. LARG contains a PDZ [post synaptic density protein (PSD95), Drosophila discs-large tumor suppressor (DIgA), and zonula occludens-1 protein (zo-1)] domain which is an 80-90 amino acid structural domain found in signaling proteins in bacteria, yeast, plants, and animals. LARG is proposed to play a role in cell polarity and microtubule dynamics and may act as a GTPase-activating protein (GAP) for the heterotrimeric Galpha(12) and Galpha(13) proteins.
    Product Specifications
    Catalog # Size Price
    LARG AntibodyReactivity: Human
    Applications: WB
    Immunogen: Between 1350 and 1400
    A301-959A100 µl (1 mg/ml) $339Add to Cart
    A301-959A-M100 µl (10 blots) $229Add to Cart
    A301-959A-T20 µl (2 blots) $50Add to Cart
    LARG AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 1494 and 1544
    A301-960A100 µl (1 mg/ml) $339Add to Cart
    A301-960A-M100 µl (10 blots) $229Add to Cart
    A301-960A-T20 µl (2 blots) $50Add to Cart
    Applications: WB, IP
    Reactivity: Human
    Includes: 1 each of A301-959A and A301-960A
    A310-694A1 Pack $472Add to Cart

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