KPNA3 Antibody

KPNA3 (karyopherin alpha 3), also known as importin alpha 4, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers. KPNA3 has also been reported to be responsible for the ligand-independent nuclear translocation of the vitamin D receptor.
    Product Specifications
    Catalog # Size Price
    KPNA3 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF, PLA
    Immunogen: Between 1 and 50
    A301-626A100 µl (0.2 mg/ml) $339Add to Cart
    KPNA3 IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human, Mouse
    Immunogen: Between 1 and 50
    IHC-00320100 µl (50+ slides) $360Add to Cart
    IHC-00320-T10 µl (5+ slides) $50Add to Cart

    Please note that Cookies and JavaScript are required for you to view this website.

    Check if you have Cookies and JavaScript enabled in your browser