KCNMA1 Antibody

KCNMA1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) is a potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. KCNMA1 is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. KCNMA1 therefore contributes to repolarization of the membrane potential, and plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity.1, maxi K channel, MaxiK, Slo-alpha, slo1, slowpoke homolog, Slo homolog, and hSlo [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q12791].
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