JMY Antibody

Junction-mediating and -regulatory protein (JMY) acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300 and increases p53/TP53-dependent transcription and apoptosis suggesting an important role in p53/TP53 stress response such as DNA damage. In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and un-branched actin filaments. It activates the Arp2/3 complex to induce branched actin filament networks and also catalyzes actin polymerization in the absence of Arp2/3, creating un-branched filaments [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N9B5]
    Product/Catalog #SpecificationsPrice
    JMY Antibody
    A302-572A
    Reactivity: Human
    Applications: IP, IHC-P, IF
    $314.00
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    JMY Antibody
    A302-573A
    Reactivity: Human
    Applications: WB
    $314.00
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    JMY Antibody AbVantage™ Pack
    A310-937A
    Applications: WB, IP, IHC-P, IF
    Reactivity: Human
    Quantity: 1 each of A302-572A and A302-573A
    $437.00
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    JMY IHC Antibody
    IHC-00718
    Applications: IHC-P, IF
    Reactivity: Human
    Quantity: 0.1 ml (50 - 250 slides)
    $360.00
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