JMY Antibody

Junction-mediating and -regulatory protein (JMY) acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300 and increases p53/TP53-dependent transcription and apoptosis suggesting an important role in p53/TP53 stress response such as DNA damage. In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and un-branched actin filaments. It activates the Arp2/3 complex to induce branched actin filament networks and also catalyzes actin polymerization in the absence of Arp2/3, creating un-branched filaments [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N9B5]
    Product Specifications
    Catalog # Size Price
    JMY AntibodyReactivity: Human
    Applications: IP, IHC-P, IF
    Immunogen: Between 1 and 50
    A302-572A100 µl (1 mg/ml) $339Add to Cart
    A302-572A-T10 µl (1 mg/ml) $50Add to Cart
    JMY AntibodyReactivity: Human
    Applications: WB
    Immunogen: Between 800 and 850
    A302-573A100 µl (0.2 mg/ml) $339Add to Cart
    A302-573A-M100 µl (10 blots) $229Add to Cart
    A302-573A-T20 µl (2 blots) $50Add to Cart
    JMY IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human
    Immunogen: Between 1 and 50
    IHC-00718100 µl (50+ slides) $360Add to Cart
    IHC-00718-T10 µl (5+ slides) $50Add to Cart
    Applications: WB, IP, IHC-P, IF
    Reactivity: Human
    Includes: 1 each of A302-572A and A302-573A
    A310-937A1 Pack $472Add to Cart

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