Itch Antibody

Itch is an HECT-type E3 ubiquitin ligase that promotes the ubiquitination of Notch. The drosophila ortholog of Itch, suppressor of deltex (SU(DX)), was originally identified as a negative regulator of the Notch pathway. Deltex is a transmembrane ligand for Notch and also has a mammalian homolog, DTX1.The human ortholog of Itch and (SU(DX)) is called AIP4 (atrophin-1-interacting protein) and was first described as a protein that interacts with the product of the gene responsible for dentatorubral and pallidoluysian atrophy (DRPLA). In mice, Itch was identified as a mutant locus in 18H mice that resulted in a fatal disease characterized by inflammation of the skin which resulted in constant itching and scarring.
    Product Specifications
    Catalog # Size Price
    Itch AntibodyReactivity: Human
    Applications: WB
    Immunogen: Between 650 to 700
    A301-992A100 µl (0.2 mg/ml) $339Add to Cart
    A301-992A-M100 µl (10 blots) $229Add to Cart
    A301-992A-T20 µl (2 blots) $50Add to Cart

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