Integrin Alpha 6 Antibody

Integrin alpha 6 forms heterodimers with integrin beta 1 or beta 4 and functions as a receptor for the extracellular matrix protein, laminin. Integrin alpha 6 is encoded by the ITGA6 gene. Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P23229].

Alternative names for Integrin Alpha 6 Antibody include CD49 antigen-like family member F antibody, VLA-6 antibody, CD49f antibody, ITGA6 antibody.