IRS1 Antibody

The insulin receptor substrate 1 (IRS1) is one of four members of the IRS family (IRS1-4) that mediates intracellular signaling downstream of the IGF1 and insulin receptors. Phosphorylation of IRS1 by activated receptors leads to binding of IRS to the SH2 domains of effector proteins such as PI3K, Grb2, nck, and SHP2. The downstream effects of insulin and IGF1 signaling via IRSs on the cell are pleiotropic and include various responses such as glucose transport, glycogen synthesis, protein synthesis, antilipolysis, and gluconeogenesis. Polymorphisms in IRS1 may contribute to the etiology of non-insulin-dependent diabetes mellitus (NIDDM).
    Product/Catalog #SpecificationsPrice
    IRS1 Antibody
    A301-157A
    Reactivity: Human
    Applications: IP
    $314.00
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    IRS1 Antibody
    A301-158A
    Reactivity: Human, Mouse
    Applications: WB, IP, IHC-P, IF
    $314.00
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    Data Sheet
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    IRS1 Antibody AbVantage™ Pack
    A310-385A
    Applications: WB, IP
    Reactivity: Human, Mouse
    Quantity: 1 each of A301-157A and A301-158A
    $437.00
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    Data Sheet
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    IRS1 IHC Antibody
    IHC-00357
    Applications: IHC-P, IF
    Reactivity: Human
    Quantity: 0.1 ml (50 - 250 slides)
    $360.00
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