IRS1 Antibody

The insulin receptor substrate 1 (IRS1) is one of four members of the IRS family (IRS1-4) that mediates intracellular signaling downstream of the IGF1 and insulin receptors. Phosphorylation of IRS1 by activated receptors leads to binding of IRS to the SH2 domains of effector proteins such as PI3K, Grb2, nck, and SHP2. The downstream effects of insulin and IGF1 signaling via IRSs on the cell are pleiotropic and include various responses such as glucose transport, glycogen synthesis, protein synthesis, antilipolysis, and gluconeogenesis. Polymorphisms in IRS1 may contribute to the etiology of non-insulin-dependent diabetes mellitus (NIDDM).
    Product Specifications
    Catalog # Size Price
    IRS1 AntibodyReactivity: Human
    Applications: IP
    Immunogen: Between 750 and 800
    A301-157A100 µl (1 mg/ml) $339Add to Cart
    A301-157A-T10 µl (1 mg/ml) $50Add to Cart
    IRS1 AntibodyReactivity: Human, Mouse
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 1192 and 1242
    A301-158A100 µl (0.2 mg/ml) $339Add to Cart
    A301-158A-M100 µl (10 blots) $229Add to Cart
    A301-158A-T20 µl (2 blots) $50Add to Cart

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