IKK-beta (Inhibitor of nuclear factor kappa B kinase subunit beta) is one of three subunits that comprise the IKK complex. The IKK complex consists of two catalytic subunits, IKK-alpha and IKK-beta, and a regulatory subunit IKK-gamma/NEMO. As a kinase, IKK functions to phosphorylate members of the NF-kappa B inhibitor proteins, the I-kappa B proteins. Phosphorylation of I-kappa B proteins results in the ubiquitination and degradation of I kappa B and the release and translocation of the NF-kappa B transcription factor to the nucleus where it may function to activate a vast number of genes.
Alternative names for
IKK-beta Antibody include IKK2 antibody,
Inhibitor of nuclear factor kappa-B kinase subunit beta antibody,
I-kappa-B kinase 2 antibody,
Nuclear factor NF-kappa-B inhibitor kinase beta antibody,
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antibody,
inhibitor of nuclear factor kappa-B kinase subunit beta antibody,
I-kappa-B-kinase beta antibody,
nuclear factor NF-kappa-B inhibitor kinase beta antibody.