AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington’s disease.
Alternative names for
HA95/AKAP8L Antibody include A-kinase anchor protein 8-like antibody, AKAP8-like protein antibody, neighbor of AKAP95 antibody, NAKAP95 antibody, NAKAP antibody, helicase A-binding protein 95 antibody, HAP95 antibody, homologous to ADAP95 protein antibody, HA95 antibody.