FOXP3 Antibody

FOXP3 (forkhead box P3) is a member of the forkhead/winged-helix family of transcription factors. Mutations in the FOXP3 gene are the cause of IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome, a rare disorder characterized by severe autoimmune disease that results in death within the first two years of life. FoxP3 is highly expressed in CD4+CD25+ regulatory T-cells (Tregs). In these cells, T-cell receptor signaling and co-stimulation results in the induction of NFAT (nuclear factor of activated T-cells) and its association with FOXP3. NFAT and FOXP3 function to regulate gene transcription that results in immune suppression.
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