FOXP3 (forkhead box P3) is a member of the forkhead/winged-helix family of transcription factors. Mutations in the FOXP3 gene are the cause of IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome, a rare disorder characterized by severe autoimmune disease that results in death within the first two years of life. FoxP3 is highly expressed in CD4+CD25+ regulatory T-cells (Tregs). In these cells, T-cell receptor signaling and co-stimulation results in the induction of NFAT (nuclear factor of activated T-cells) and its association with FOXP3. NFAT and FOXP3 function to regulate gene transcription that results in immune suppression.
Alternative names for
FOXP3 Antibody include Scurfin antibody,
forkhead box P3 antibody,
Forkhead box protein P3 antibody,
forkhead box protein P3 antibody,
immunodeficiency, polyendocrinopathy, enteropathy, X-linked antibody,
immune dysregulation, polyendocrinopathy, enteropathy, X-linked antibody.