Tumor necrosis factor receptor superfamily member 6, FAS, functions as the receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated FAS receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) which mediate apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P25445].
Alternative names for
FAS Antibody include FASLG receptor antibody, apoptosis-mediating surface antigen FAS antibody, Apo-1 antigen antibody, CD95 antibody, TNFRSF6 antibody, APT1 antibody, FASTM antibody, FAS1 antibody.