BRCA2 was identified as a gene with germline mutations that predisposes women to breast cancer. An important function of BRCA2 involves its direct interaction with RAD51 and the process of homologous recombination in DNA double strand break repair. BRCA2 and BRCA1 primary sequences are not similar; however the proteins exhibit similar patterns of expression and sub-cellular localization. Although the phenotype of disruptions of BRCA2 is similar to BRCA1, BRCA2 appears to possess functions distinct from BRCA1.
Alternative names for
FANCD1 Antibody include breast cancer type 2 susceptibility protein antibody, Fanconi anemia group D1 protein antibody, FAC antibody, FACD antibody, FAD1 antibody, FANCD1 antibody, FANCB antibody, BRCC2 antibody.