ErbB2 Antibody

ErbB2 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor; EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ErbB2 receptor is the only member that does not interact with a ligand, but instead functions as a heterodimeric partner to coordinate signals from other ligand bound ErbB receptors. Amplification and/or overexpression of ErbB2 have been reported in many cancers.
    Product Specifications
    Catalog # Size Price
    ErbB2 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 975 and 1025
    A300-621A100 µl (0.2 mg/ml) $339Add to Cart
    ErbB2 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 1200 and 1250
    A300-622A100 µl (0.2 mg/ml) $339Add to Cart
    ErbB2 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF, PLA
    Immunogen: Between 1200 and C-term
    A300-623A100 µl (0.2 mg/ml) $339Add to Cart
    ErbB2 IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human
    Immunogen: Between 1200 and C-term
    IHC-00032100 µl (50 slides) $360Add to Cart
    Applications: WB, IP, IHC-P, IF, PLA
    Reactivity: Human
    Includes: 1 each of A300-621A, A300-622A and A300-623A
    A310-183A1 Pack $707Add to Cart

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