The epidermal growth factor receptor (EGFR) is a membrane spanning tyrosine kinase receptor for epidermal growth factor (EGF) and other ligands of the EGF family such as TGF-alpha, amphiregulin, betacellulin, epiregulin and heparin-binding EGF-like growth factor. Upon ligand binding, the EGFR homodimerizes or heterodimerizes with other ErbB receptor family members and tranduces a downstream signal via the ras-raf-mitogen activated protein kinase pathway or the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Signals from the EGFR function to influence cell proliferation, differentiation, and development.
Alternative names for
EGFR Antibody include
Epidermal growth factor receptor antibody,
Proto-oncogene c-ErbB-1 antibody,
Receptor tyrosine-protein kinase erbB-1 antibody,
epidermal growth factor receptor antibody,
proto-oncogene c-ErbB-1 antibody,
cell growth inhibiting protein 40 antibody,
cell proliferation-inducing protein 61 antibody,
receptor tyrosine-protein kinase erbB-1 antibody,
avian erythroblastic leukemia viralv-erb-b) oncogene homolog antibody.