Dorfin is an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Dorfin specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.uniprot.org/uniprot/Q9NV58].
Alternative names for
Dorfin Antibody include p38 antibody,
E3 ubiquitin-protein ligase RNF19A antibody,
Double ring-finger protein antibody,
RING finger protein 19A antibody,
ring finger protein 19A, E3 ubiquitin protein ligase antibody,
double ring-finger protein antibody,
ring-IBR-ring domain containing protein
protein p38 interacting with transcription factor Sp1 antibody.