DTL/CDT2 is a component of the CUL4A-DDB1 E3 ubiquitinating complex and plays a role in downregulating CDT1, an essential component of pre-replication complexes (Pre-RC) that ensures the genome is replicated only once per cycle. As part of the CUL4A-DDB1 E3 ligase complex DTL/CDT2 is also involved in the regulation of other proteins involved in the G2/M cell cycle checkpoint.
Alternative names for
DTL/CDT2 Antibody include DTL antibody,
Denticleless protein homolog antibody,
DDB1- and CUL4-associated factor 2 antibody,
Lethal2) denticleless protein homolog antibody,
Retinoic acid-regulated nuclear matrix-associated protein antibody,
denticleless E3 ubiquitin protein ligase homologDrosophila) antibody,
denticleless homolog antibody,
DDB1 and CUL4 associated factor 2 antibody,
lethal2) denticleless protein homolog antibody,
RA regulated nuclear matrix associated protein antibody,
RA-regulated nuclear matrix-associated protein antibody,
retinoic acid-regulated nuclear matrix-associated protein antibody.