DOCK7 Antibody

Dedicator of cytokinesis protein 7 (DOCK7) functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. DOCK7 does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96N67].
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