DOCK80 is a non-conventional Rho-guanine nucleotide exchange factor (Rho-GEF) that functions to activate the small GTPases Rac and Cdc42. It is a member of the CZH (CDM-zizimin homology) family of proteins that contain two highly conserved domains, CZH1 and CZH2. Dock180 functions to activate Rac and regulate cell adhesion, cell spreading, migration and phagocytosis.
Alternative names for
DOCK180 Antibody include dedicator of cytokinesis protein 1 antibody, 180 kDa protein downstream of CRK antibody, DOCK1 antibody, ced5 antibody.