DDX26/DICE1 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX26/DICE1 is a subunit of the integrator complex involved in 3’-end processing of snRNAs. DDX26/DICE1 is implicated as a tumor suppressor, and its ectopic expression has been shown to inhibit tumor cell growth.
Alternative names for
DICE1/DDX26 Antibody include integrator complex subunit 6 antibody, Int6 antibody, protein deleted in cancer 1 antibody, protein DDX26 antibody, DBI-1 antibody, deleted in cancer 1 antibody, INTS6 antibody, DDX26A antibody, HDB antibody, Nochl2 antibody, DKFZP434B105 antibody.