DHX36 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX36 expression is highest in testis and plays a role in 3’-5’ degradation of AU-rich RNAs. Interestingly, DHX36 has also been observed to function as a G4-DNA resolvase. In this capacity DHX36 catalyzes the resolution of highly stable G4- DNA structures that form in guanine-rich regions of single-stranded DNA.
Alternative names for
DHX36 Antibody include
G4 resolvase-1 antibody,
Probable ATP-dependent RNA helicase
DEAH box protein 36 antibody,
MLE-like protein 1 antibody,
RNA helicase associated with AU-rich element ARE antibody,
DEAHAsp-Glu-Ala-His) box polypeptide 36 antibody,
probable ATP-dependent RNA helicase
DEAD/HAsp-Glu-Ala-Asp/His) box polypeptide 36 antibody.