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A-Z / DFF45/DFFA
 

DFF45/DFFA Antibody

 
DNA fragmentation factor (DFF45/DFFA) is a component of DFF, the principle DNA endonuclease responsible for nucleosomal DNA cleavage during apoptosis. In the DFF complex, DFF45/DFFA heterodimerizes with DFF40 and is a substrate of the apoptotic effector, caspase 3. Initiation of the cellular apoptotic program results in the activation of caspase 3 and the cleavage and release of DFF45 from its heterodimeric partner, DFF40. The release of DFF40 from the inhibitory activity of DFF45 allows DFF40 to function as a DNA endonuclease to promote chromosomal DNA fragmentation. A 35 kDa splice variant of DFF45, DFF35, also exists and functions as a chaperone and alternate heterodimeric partner for DFF40. Alternate names for DFF45/DFFA include DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, inhibitor of CAD, ICAD, DFF1, and DFF-45.
 
Product / Catalog #SpecificationsPrice
DFF45/DFFA Antibody
A301-420A		Applications: WB, IP
Reactivity: Human
Quantity: 0.1 ml (20 - 100 blots)
$280.00
Data Sheet
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DFF45/DFFA IHC Antibody
IHC-00291		Applications: IHC, IHC-IF
Reactivity: Human
Quantity: 0.1 ml (50 - 250 slides)
$360.00
Data Sheet
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DFF45/DFFA Blocking Peptide
BP301-420		Applications: Blocks A301-420A
Quantity: 50 mcg
$115.00
Data Sheet
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