DFF45/DFFA Antibody

DNA fragmentation factor (DFF45/DFFA) is a component of DFF, the principle DNA endonuclease responsible for nucleosomal DNA cleavage during apoptosis. In the DFF complex, DFF45/DFFA heterodimerizes with DFF40 and is a substrate of the apoptotic effector, caspase 3. Initiation of the cellular apoptotic program results in the activation of caspase 3 and the cleavage and release of DFF45 from its heterodimeric partner, DFF40. The release of DFF40 from the inhibitory activity of DFF45 allows DFF40 to function as a DNA endonuclease to promote chromosomal DNA fragmentation. A 35 kDa splice variant of DFF45, DFF35, also exists and functions as a chaperone and alternative heterodimeric partner for DFF40.
    Product Specifications
    Catalog # Size Price
    DFF45/DFFA AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 271 and 331
    A301-420A100 µl (0.2 mg/ml) $339Add to Cart
    A301-420A-M100 µl (10 blots) $229Add to Cart
    A301-420A-T20 µl (2 blots) $50Add to Cart
    DFF45/DFFA IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human
    Immunogen: Between 271 and 331
    IHC-00291100 µl (50+ slides) $360Add to Cart
    IHC-00291-T10 µl (5+ slides) $50Add to Cart
    Applications: WB, IP, IHC-P, IF
    Reactivity: Human
    Includes: 1 each of A301-420A and A301-421A
    A310-493A1 Pack $472Add to Cart

    Please note that Cookies and JavaScript are required for you to view this website.

    Check if you have Cookies and JavaScript enabled in your browser