DFF45/DFFA Antibody

DNA fragmentation factor (DFF45/DFFA) is a component of DFF, the principle DNA endonuclease responsible for nucleosomal DNA cleavage during apoptosis. In the DFF complex, DFF45/DFFA heterodimerizes with DFF40 and is a substrate of the apoptotic effector, caspase 3. Initiation of the cellular apoptotic program results in the activation of caspase 3 and the cleavage and release of DFF45 from its heterodimeric partner, DFF40. The release of DFF40 from the inhibitory activity of DFF45 allows DFF40 to function as a DNA endonuclease to promote chromosomal DNA fragmentation. A 35 kDa splice variant of DFF45, DFF35, also exists and functions as a chaperone and alternative heterodimeric partner for DFF40.
    Product/Catalog #SpecificationsPrice
    DFF45/DFFA Antibody
    A301-420A
    Reactivity: Human
    Applications: WB, IP, IHC-P, IF
    $314.00
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    DFF45/DFFA IHC Antibody
    IHC-00291
    Applications: IHC-P, IF
    Reactivity: Human
    Quantity: 0.1 ml (50 - 250 slides)
    $360.00
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    Data Sheet
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