DBF4 Antibody

The DBF4 gene was originally identified in replication mutants of S. cerevisiae that exhibited a “dumbbell former” phenotype characterized by a cell with a single large bud. The human homolog was later isolated in a two-hybrid screen for proteins that interact with the human Cdc7-related kinase (huCdc7), a conserved kinase that phosphorylates MCM2 and MCM3 and is required for the G1/S transition. DBF4 functions as a regulatory subunit for the human Cdc7 kinase and is essential for the initiation of DNA repair.

Alternative names for DBF4 Antibody include activator of S-phase kinase antibody, chiffon homolog A antibody, DBF4-type zinc finger-containing protein 1 antibody, ASK antibody, DBF4A antibody, ZDBF1 antibody, CHIF antibody.