Cyclin H Antibody

Cyclin H is a member of the cyclin family of regulatory proteins that associate with and activate cyclin-dependent kinases (CDKs) to regulate cell cycle progression. The hallmark characteristic of cyclins is the periodicity of their expression and activity that is regulated transcriptionally and post-transcriptionally via phosphorylation and ubiquitination. Cyclin H associates with CAK [cyclin-dependent activating kinase (CDK) activating kinase], also known as CDK7 or p40MO15. Cyclin H is part of a group of cyclins that are involved in transcriptional regulation. The transcriptional regulating cyclins include cyclin C, H, K, L1, L2, T1, and T2 which associate with CDK7, -8, -9, -10 and -12. The p40MO15(cdk7)/cyclin H/MAT1 complex localizes to the nucleus and is a subunit of the general transcription factor IIH. This complex functions to activate CDKs as well as phosphorylate several components of the transcriptional machinery.
    Product Specifications
    Catalog # Size Price
    Cyclin H AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 25 and 75
    A301-674A100 µl (1 mg/ml) $339Add to Cart
    A301-674A-M100 µl (10 blots) $229Add to Cart
    A301-674A-T20 µl (2 blots) $50Add to Cart
    Cyclin H AntibodyReactivity: Human
    Applications: IP
    Immunogen: Between 225 and 275
    A301-675A100 µl (1 mg/ml) $339Add to Cart
    A301-675A-T10 µl (1 mg/ml) $50Add to Cart
    Applications: WB, IP
    Reactivity: Human
    Includes: 1 each of A301-674A and A301-675A
    A310-593A1 Pack $472Add to Cart

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