Claspin Antibody

Claspin is a checkpoint protein that interacts with and regulates checkpoint kinase 1 (Chk1) in response to replication stress. The interaction between claspin and Chk1 has been demonstrated to be required for ATR-dependent Chk1 activation. The interaction involves the phosphorylation of claspin that may be accomplished by Chk1 kinase activity. Claspin has been found to localize to chromatin in both the presence and absence of damaged DNA and to associate with PCNA, as an essential component of the DNA replication machinery. This association with the replication machinery may indicate a role for claspin in linking replication to DNA damage signaling and Chk1 activation.
    Product/Catalog #SpecificationsPrice
    Claspin Antibody
    A300-265A
    Reactivity: Human
    100% Sequence Identity:
    Applications: WB
    $314.00
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    Data Sheet
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    Claspin Antibody
    A300-266A
    Reactivity: Human
    Applications: WB, IP, IHC-P, IF, PLA
    $314.00
    Bulk Quote
    Data Sheet
    Add to Cart
    Claspin Antibody
    A300-267A
    Reactivity: Human
    100% Sequence Identity:
    Applications: WB, IP
    $314.00
    Bulk Quote
    Data Sheet
    Add to Cart
    Claspin Antibody AbVantage™ Pack
    A310-073A
    Applications: WB, IP, PLA, IHC-P, IF
    Reactivity: Human
    Quantity: 1 each of A300-265A, A300-266A and A300-267A
    $655.00
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    Data Sheet
    Add to Cart
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