CSN3 Antibody

CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.
    Product Specifications
    Catalog # Size Price
    CSN3 AntibodyReactivity: Human
    Applications: WB, IHC-P, IF
    Immunogen: Between 325 and 375
    A300-012A100 µl (1 mg/ml) $339Add to Cart
    A300-012A-M100 µl (10 blots) $229Add to Cart
    A300-012A-T20 µl (2 blots) $50Add to Cart
    CSN3 AntibodyReactivity: Human
    Applications: WB
    Immunogen: Between 325 and 375
    A300-029A100 µl (1 mg/ml) $339Add to Cart
    A300-029A-M100 µl (10 blots) $229Add to Cart
    A300-029A-T20 µl (2 blots) $50Add to Cart
    CSN3 IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human
    Immunogen: Between 325 and 375
    IHC-00111100 µl (50+ slides) $360Add to Cart
    IHC-00111-T10 µl (5+ slides) $50Add to Cart
    Applications: WB, IHC-P, IF
    Reactivity: Human
    Includes: 1 each of A300-012A and A300-029A
    A310-001A1 Pack $472Add to Cart

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