CSN3 Antibody

CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.
    Product/Catalog #SpecificationsPrice
    CSN3 Antibody
    A300-012A
    Reactivity: Human
    Applications: WB, IHC-P, IF
    $314.00
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    CSN3 Antibody
    A300-029A
    Reactivity: Human
    Applications: WB
    $314.00
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    CSN3 Antibody AbVantage™ Pack
    A310-001A
    Applications: WB, IHC-P, IF
    Reactivity: Human
    Quantity: 1 each of A300-012A and A300-029A
    $437.00
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    CSN3 IHC Antibody
    IHC-00111
    Applications: IHC-P, IF
    Reactivity: Human
    Quantity: 0.1 ml (50 - 250 slides)
    $360.00
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