Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.
Alternative names for
CRM1 Antibody include Exportin-1 antibody,
Chromosome region maintenance 1 protein homolog antibody,
exportin 1CRM1 homolog, yeast) antibody,
CRM1, yeast, homolog antibody,
exportin 1CRM1, yeast, homolog) antibody,
chromosome region maintenance 1 protein homolog antibody,
exportin-1required for chromosome region maintenance) antibody.