CPSF30 Antibody

CPSF30/CPSF4 (cleavage and polyadenylation specific factor 4, 30 kDa subunit) is a subunit of the cleavage and polyadenylation specificity factor (CPSF) involved in mammalian mRNA 3’-end processing. CPSF, along with CstF (cleavage and stimulation factor), is critical for the recognition of cis-acting sequence elements on the pre-mRNA that dictate the site of cleavage and subsequent polyadenylation. CPSF exists as a complex of four proteins that includes CPSF160/CPSF1, CPSF100/CPSF2, CPSF73/CPSF3, and CPSF30/CPSF4. Studies of the Arabidopsis CPSF30/CPSF4 ortholog have revealed that CPSF30/CPSF4 may function as a processing endonuclease and interacts with Fip1, an integral subunit of CPSF.
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