COBRA1 Antibody

COBRA1 (Cofactor of BRCA1) is also known as NELFB (negative elongation factor E). NELFB is one of four subunits that make up the NELF transcription elongation factor. The four subunits of NELF are NELF A (WHSC2), NELFB, either NELFC or NELFD, and NELFE. NELF, along with DRB sensitivity-inducing factor (DSIF), functions to cause transcriptional pausing of RNA polymerase II. COBRA1 was originally identified in a yeast two-hybrid screen of a human ovary cDNA library using the BRCA COOH terminus repeat, BRCT1, as the bait protein. In this study, COBRA1 was found to be involved in BRCT1-mediated chromatin remodeling. COBRA1 has also been found to interact with several nuclear receptors such as ERalpha and androgen receptor to modulate their transcriptional activity.
    Product Specifications
    Catalog # Size Price
    COBRA1 AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 25 and 75
    A301-911A100 µl (1 mg/ml) $339Add to Cart
    A301-911A-M100 µl (10 blots) $229Add to Cart
    A301-911A-T20 µl (2 blots) $50Add to Cart
    COBRA1 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 530 and 580
    A301-912A100 µl (0.2 mg/ml) $339Add to Cart
    A301-912A-M100 µl (10 blots) $229Add to Cart
    A301-912A-T20 µl (2 blots) $50Add to Cart

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