CIZ1 Antibody

CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.
    Product Specifications
    Catalog # Size Price
    CIZ1 AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 325 and 375
    A301-496A100 µl (0.2 mg/ml) $339Add to Cart
    A301-496A-M100 µl (10 blots) $229Add to Cart
    A301-496A-T20 µl (2 blots) $50Add to Cart
    CIZ1 AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 848 and 898
    A301-497A100 µl (1 mg/ml) $339Add to Cart
    A301-497A-M100 µl (10 blots) $229Add to Cart
    A301-497A-T20 µl (2 blots) $50Add to Cart
    Applications: WB, IP
    Reactivity: Human
    Includes: 1 each of A301-496A and A301-497A
    A310-523A1 Pack $472Add to Cart

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