CHD3 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD3 is a key component of the NuRD (nucleosomal remodeling) complex and directly interacts with histone deacetylases 1 and 2, ATR, and TRIM 27. Studies in several species suggest a role for CHD3 in the repression of developmental genes.
Alternative names for
CHD3 Antibody include Mi2-alpha antibody,
Chromodomain-helicase-DNA-binding protein 3 antibody,
Mi-2 autoantigen 240 kDa protein antibody,
Zinc finger helicase antibody,
chromodomain helicase DNA binding protein 3 antibody,
chromodomain-helicase-DNA-binding protein 3 antibody,
zinc finger helicase antibody,
mi-2 autoantigen 240 kDa protein antibody,
zinc-finger helicaseSnf2-like) antibody.