CDT2/DTL Antibody

DTL/CDT2 is a component of the CUL4A-DDB1 E3 ubiquitinating complex and plays a role in downregulating CDT1, an essential component of pre-replication complexes (Pre-RC) that ensures the genome is replicated only once per cycle. As part of the CUL4A-DDB1 E3 ligase complex DTL/CDT2 is also involved in the regulation of other proteins involved in the G2/M cell cycle checkpoint.

Alternative names for CDT2/DTL Antibody include Denticleless Homolog antibody, CDT2 antibody, Chromatin Licensing and DNA Replication Factor 2 antibody, L2DTL antibody, Lethal(2) Denticleless Protein Homolog antibody, DCAF2 antibody, DDB1- and Cul4-Associated Factor 2 antibody, RAMP antibody, Retinoic-Acid Regulated Nuclear Matrix-associated Protein antibody, CDW1 antibody.