CBF-beta (isoform 2) Antibody

Core-binding factor subunit beta (CBF-beta) is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13951].

Alternative names for CBF-beta (isoform 2) Antibody include polyomavirus enhancer-binding protein 2 beta subunit antibody, PEA2-beta antibody, PEBP2-beta antibody, SL3-3 enhancer factor 1 beta subunit antibody, SL3/AKV core-binding factor beta subunit antibody, CBF-beta antibody.