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A-Z / BRCC36
 

BRCC36 Antibody

 
BRCA1/BRCA2-containing complex subunit 36 (BRCC36) is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. BRCC36 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, BRCC36 specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P46736]
 
Product / Catalog #SpecificationsPrice
BRCC36 Antibody
A302-517A		Applications: WB, IP
Reactivity: Human, Mouse
Quantity: 0.1 ml (20 - 100 blots)
$280.00
Data Sheet
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BRCC36 Blocking Peptide
BP302-517		Applications: Blocks A302-517A
Quantity: 50 mcg
$115.00
Data Sheet
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