BRCC36 Antibody

BRCA1/BRCA2-containing complex subunit 36 (BRCC36) is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. BRCC36 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, BRCC36 specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) [taken from the Universal Protein Resource (UniProt)].
    Product Specifications
    Catalog # Size Price
    BRCC36 AntibodyReactivity: Human, Mouse
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 266 and 316
    A302-517A100 µl (1 mg/ml) $339Add to Cart
    A302-517A-M100 µl (10 blots) $229Add to Cart
    A302-517A-T20 µl (2 blots) $50Add to Cart
    BRCC36 IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human
    Immunogen: Between 266 and 316
    IHC-00715100 µl (50+ slides) $360Add to Cart
    IHC-00715-T10 µl (5+ slides) $50Add to Cart

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