BRAP Antibody

BRCA1-associated protein (BRAP) negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. BRAP acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. BRAP may also act as a cytoplasmic retention protein with a role in regulating nuclear transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z569].

Alternative names for BRAP Antibody include BRAP2 antibody, impedes mitogenic signal propagation antibody, IMP antibody, RING finger protein 52 antibody, renal carcinoma antigen NY-REN-63 antibody, RNF52 antibody.