ARNT Antibody

Aryl hydrocarbon receptor nuclear translocator (ARNT) is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. ARNT forms a complex with the ligand-bound Ah receptor, and is required for receptor function. ARNT has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia [taken from NCBI Entrez Gene (GeneID: 405)].
    Product Specifications
    Catalog # Size Price
    ARNT AntibodyReactivity: Human
    Applications: IP, IHC-P, IF
    Immunogen: Between 1 and 50
    A302-764A100 µl (1 mg/ml) $339Add to Cart
    A302-764A-T10 µl (1 mg/ml) $50Add to Cart
    ARNT AntibodyReactivity: Human
    Applications: IP, IHC-P, IF
    Immunogen: Between 575 and 625
    A302-765A100 µl (1 mg/ml) $339Add to Cart
    A302-765A-T10 µl (1 mg/ml) $50Add to Cart
    Applications: IP, IHC-P, IF
    Reactivity: Human
    Includes: 1 each of A302-764A and A302-765A
    A311-013A1 Pack $472Add to Cart

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