AKAP8L/HA95 Antibody

AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington’s disease.
    Product Specifications
    Catalog # Size Price
    AKAP8L/HA95 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 525 and 575
    A301-365A100 µl (0.2 mg/ml) $339Add to Cart
    A301-365A-M100 µl (10 blots) $229Add to Cart
    A301-365A-T20 µl (2 blots) $50Add to Cart
    AKAP8L/HA95 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 596 and 646
    A301-366A100 µl (0.2 mg/ml) $339Add to Cart
    A301-366A-M100 µl (10 blots) $229Add to Cart
    A301-366A-T20 µl (2 blots) $50Add to Cart
    AKAP8L/HA95 IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human
    Immunogen: Between 596 and 646
    IHC-00277100 µl (50+ slides) $360Add to Cart
    IHC-00277-T10 µl (5+ slides) $50Add to Cart
    Applications: WB, IP, IHC-P, IF
    Reactivity: Human
    Includes: 1 each of A301-365A and A301-366A
    A310-472A1 Pack $472Add to Cart

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