Axin interactor and dorsalization-associated protein (AIDA) acts as a ventralizing factor during embryogenesis. By similarity AIDA is proposed to inhibit axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96BJ3]
Alternative names for
AIDA Antibody include AIDA antibody, axin interactor antibody, dorsalization associated antibody.