Zinc-finger protein A20 was identified as a transcript that was rapidly induced by tumor-necrosis factor alpha (TNF-alpha). A20 is an essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, A20 deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P21580].
Alternative names for
A20 Antibody include TNFAIP3 antibody,
Tumor necrosis factor alpha-induced protein 3 antibody,
OTU domain-containing protein 7C antibody,
Putative DNA-binding protein
Zinc finger protein
tumor necrosis factor, alpha-induced protein 3 antibody,
tumor necrosis factor alpha-induced protein 3 antibody,
zinc finger protein
TNF alpha-induced protein 3 antibody,
putative DNA-binding protein
tumor necrosis factor inducible protein A20 antibody.