TOPORS Antibody

TOPORS (topoisomerase I-binding RS protein) was identified in a a yeast two-hybrid screen for proteins that bind the N-terminus of topoisomerase I. TOPORS contains a RING-type zinc-finger domain and an RS-rich region. TOPORS has been found to possess both ubiquitin and SUMO-1 E3 ligase activity. It can ubiquitinate and sumoylate p53 and may possibly function as a tumor suppressor. Defects in TOPORS are the cause of retinitis pigmentosa type 31.
TOPORS
TOP1 binding arginine/serine rich protein
E3 ubiquitin-protein ligase Topors
:  LUN p53-binding protein 3 P53BP3 retinitis pigmentosa 31 (autosomal dominant) RP31 SUMO1-protein E3 ligase Topors topoisomerase I binding, arginine/serine-rich topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase Topoisomerase I-binding arginine/serine-rich protein topoisomerase I-binding RING finger protein TP53BPL tumor suppressor p53-binding protein 3 More... Less...
Product
Specifications
Ordering Information
Human
WB, IP, IHC-P
Between 995 and 1045
100
$339
$229
$99
Human
IHC-P, IF
Between 995 and 1045
100
$360
$99