PAN3 Antibody

PAB-dependent poly(A)-specific ribonuclease subunit PAN3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q58A45].
PAN3
PAN3 poly(A) specific ribonuclease subunit
PAB-dependent poly(A)-specific ribonuclease subunit PAN3
:  hPan3 PAB1P-dependent poly(A)-nuclease PAB-dependent poly(A)-specific ribonuclease subunit 3 PABP1-dependent poly A-specific ribonuclease subunit PAN3 PABP-dependent poly(A) nuclease 3 PAN deadenylation complex subunit 3 PAN3 poly(A) specific ribonuclease subunit homolog PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) More... Less...
Product
Specifications
Ordering Information
Human
WB, IP
Between 175 and 225
100
$339
$229
$99