PAN2/USP52 Antibody

PAB-dependent poly(A)-specific ribonuclease subunit PAN2 is the catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q504Q3].
PAN2
PAN2 poly(A) specific ribonuclease subunit
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
:  hPAN2 inactive ubiquitin carboxyl-terminal hydrolase 52 KIAA0710 PAB1P-dependent poly(A)-nuclease PAB-dependent poly(A)-specific ribonuclease subunit 2 PABP-dependent poly(A) nuclease 2 PAN deadenylation complex catalytic subunit 2 PAN2 homolog, PABP1 dependent poly A specific ribonuclease subunit (S. cerevisiae) PAN2 poly(A) specific ribonuclease subunit homolog PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) PAN2 polyA specific ribonuclease subunit ubiquitin specific peptidase 52 ubiquitin specific protease 52 USP52 More... Less...
Product
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Human, Mouse
WB, IP
Between 1 and 50
100
$339
$229
$99