MDC1/Nfbd1 Antibody

Mediator of DNA damage checkpoint protein 1 (Mdc1) is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. It is also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5PSV9].
Mdc1
mediator of DNA damage checkpoint 1
Mediator of DNA damage checkpoint protein 1
:  6820401C03 AA413496 Em:AB023051.5 homologue to Drosophila photoreceptor protein calphotin KIAA0170 mediation of DNA damage checkpoint 1 mediator of DNA-damage checkpoint 1 mKIAA0170 Nfbd1 nuclear factor with BRCT domains 1
Product
Specifications
Ordering Information
Human
WB, IP, PLA
Between 475 and 525
100
$339
$229
$99
Human
WB, IP, IHC-P
Between 925 and 975
100
$339
Human
WB, IP, IHC-P
Between 1375 and 1425
100
$339
$229
$99
Human
100
Includes: 1 each of A300-051A, A300-052A and A300-053A
$707
Includes: 1 each of A300-051A, A300-052A and A300-053A
Human
IHC-P
Between 1375 and 1425
100
$360
$99
Mouse
IP
Between 900 and 950
100
$339
$99