IWS1 Antibody

IWS1 homolog is a transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. IWS1 acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96ST2].
IWS1
IWS1, SUPT6H interacting protein
Protein IWS1 homolog
:  DKFZp761G0123 FLJ10006 FLJ14655 FLJ32319 interacts with Spt6 IWS1 homolog IWS1 homolog (S. cerevisiae) IWS1-like protein
Product
Specifications
Ordering Information
Human, Mouse
WB, IP
Between 1 to 50
100
$339
$229
$99