FIP1 Antibody

FIP1 was originally identified as Rhe (rearranged in hypereosinophilia) and part of a fusion protein encoded by a genetic rearrangement between the N-terminal region of FIP1 (Rhe) and the C-terminal region of the platelet-derived growth factor receptor alpha (PDGFRalpha). The fusion protein exhibits aberrant tyrosine kinase activity and is associated with hypereosinophilic syndrome (HES), a rare hematologic disorder characterized by an overproduction of eosinophils that results in organ damage. FIP1 was also identified as FIP1-like 1 in a database search for a human homolog of the yeast Fip1p (factor interacting with PAP), a subunit of the yeast 3’-end processing complex, CPF (cleavage and polyadenylation factor). Human FIP1 was similarly found to interact with PAP and CPSF160 as part of the human CPSF (cleavage and polyadenylation specificity factor) complex. In association with CPSF160, FIP1 is able to recognize U-rich elements on pre-mRNA and stimulate PAP activity.
FIP1L1
factor interacting with PAPOLA and CPSF1
Pre-mRNA 3'-end-processing factor FIP1
:  DKFZp586K0717 factor interacting with PAP FIP1 FIP1 like 1 FIP1 like 1 (S. cerevisiae) FIP1L1 cleavage and polyadenylation specific factor subunit FIP1-like 1 protein hFip1 rearranged in hypereosinophilia Rhe
Product
Specifications
Ordering Information
Human
WB, IP, IHC-P
Between 1 and 50
100
$339
$229
$99
Human
WB, IP, IHC-P
Between 544 and 594
100
$339
$229
$99
Human
100
Includes: 1 each of A301-461A and A301-462A
$472
Includes: 1 each of A301-461A and A301-462A
Human
IHC-P, IF
Between 544 and 594
100
$360
$99