Exonuclease 1 Antibody

Exonuclease 1 is a 5'-3' double-stranded DNA exonuclease which may also possess a cryptic 3'-5' double-stranded DNA exonuclease activity. Exonuclease 1 functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. It also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Exonuclease 1 is required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes and is essential for male and female meiosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UQ84].
EXO1
exonuclease 1
Exonuclease 1
:  Exonuclease I HEX1 hExo1 hExoI rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
Product
Specifications
Ordering Information
Human
WB, IP
Between 725 and 775
100
$339
$229
$99
Human
WB, IP
Between 796 and 846
100
$339
$229
$99
Human
100
Includes: 1 each of A302-639A and A302-640A
$472
Includes: 1 each of A302-639A and A302-640A