PSMC1 Antibody

Proteasome (prosome, macropain) 26S subunit, ATPase1 (PSMC1) is a subunit of the 26S proteasome, a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMC1 is one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. PSMC1 also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, PSMC1 interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder [taken from NCBI Entrez Gene (Gene ID: 5700)].
PSMC1
proteasome 26S subunit, ATPase 1
26S protease regulatory subunit 4
:  26S proteasome AAA-ATPase subunit RPT2 P26S4 p56 proteasome (prosome, macropain) 26S subunit, ATPase, 1 proteasome 26S ATPase subunit 1 proteasome 26S subunit ATPase 1 proteasome 26S subunit, ATPase, 1 S4
Product
Specifications
Ordering Information
Human, Mouse
WB
Between 50 and 100
100
$339
$229
$99
Human, Mouse
WB, IP, IHC-P
Between 390 and 440
100
$339
$229
$99
Human, Mouse
100
Includes: 1 each of A303-820A and A303-821A
$472
Includes: 1 each of A303-820A and A303-821A