PPM1D Antibody

Members of the protein phosphatase 2C (PP2C) family of isoenzymes are serine/threonine protein phosphatases that act as monomers, are magnesium or manganese dependent, and are structurally distinct from PP1, PP2A, and PP2B protein phosphatases. There are 14 mammalian PP2C genes that encode for members of the PP2C family of isoenzymes. Members of this family include PP2C alpha (PPM1A), PP2C beta (PPM1B), PP2C gamma (PPM1G), and PP2C delta (PPM1D). PPM1D has been demonstrated to negatively regulate cell growth. PPM1D dephosphorylates RSK (p90 ribosomal S6 kinase) and regulates ChK2 in the DNA damage response PPM1D acts within the MAPK pathway and can inactivate p38 MAPK which leads to subsequent p53 inactivation PPM1D is amplified in breast tumors and has been demonstrated to enhance steroid hormone action.
PPM1D
protein phosphatase, Mg2+/Mn2+ dependent 1D
Protein phosphatase 1D
:  p53-induced protein phosphatase 1 PP2C-DELTA protein phosphatase 1D magnesium-dependent, delta isoform protein phosphatase 2C delta isoform Protein phosphatase 2C isoform delta protein phosphatase 2C, delta isoform Protein phosphatase magnesium-dependent 1 delta protein phosphatase Mg2+/Mn2+ dependent 1D protein phosphatase Wip1 protein phosphatase, Mg2+/Mn2+ dependent, 1D wild-type p53-induced phosphatase 1 Wip1 More... Less...
Product
Specifications
Ordering Information
Human
WB, IP
Between 500 and 550
100
This item is backordered. Please contact Bethyl Customer Support at 1-800-338-9579 if you are interested in purchasing this item. Expected Release late October 2017 (Updated 10/10/2017)
$229
$99